MOPS sodium salt, a biological buffer, is frequently used in the field of biochemistry and molecular biological research. Buffers are chemicals capable of absorbing acid or alkali, in solution, so that the addition of acid or alkali results in small changes in the pH of the solution.


MOPS sodium salt (CAS 71119-22-7), chemical name: 3-(N-morpholino)propanesulfonate, is a white powder at room temperature with excellent water solubility properties.

With a working pH range between 6.5 and 7.9, it is commonly used in biochemistry and molecular biology, mainly for protein extraction and purification, and RNA isolation by electrophoresis. Most of the material we supply is used in the production of culture media for growth and diagnosis of bacteria and yeast, especially for food microbiology.

Special Considerations in Specific Applications

For specific applications, the following should be considered:

  • Concentrations greater than 20 mM can affect growth in eukaryotic cell cultures.
  • MOPS can form complexes with metals, nucleic acids, and lipids, possibly affecting experiments.
  • In the presence of glucose, it can partially degrade upon autoclaving.

For more details about fine chemical products, please consult our product catalog. At DC Fine Chemicals, as fine chemical suppliers located in Spain and the United Kingdom, we offer products for multiple uses. If you cannot find the product you need, please ask. We will be delighted to help you!

Relevant bibliographic references

Taha, M., Gupta, B. S., Khoiroh, I., & Lee, M. J. (2011). Interactions of Biological Buffers with Macromolecules: The Ubiquitous “Smart” Polymer PNIPAM and the Biological Buffers MES, MOPS, and MOPSO. Macromolecules, 44(21), 8575-8589. c

Carson, S. D., Hafenstein, S., & Lee, H. (2017). MOPS and coxsackievirus B3 stability. Virology, 501, 183-187.