Also known as triphosgene, it is a compound that allows efficient syntheses due to its versatility. It is a solid and potentially toxic element, so its handling has to be governed by its properties.

Below we will take a closer look at this type of excipient. Read on to learn more about bis(trichloromethyl) carbonate and don’t forget that on the DC Fine Chemicals website you will find multiple options to get the fine chemical products you need. As always of the highest quality, visit our catalogue!

Solid form and toxic properties

In the late 20th century, triphosgene was rediscovered, having been found several decades earlier. It is now widely used in the research and development sector of industry, such as API active pharmaceutical ingredients, as well as agrochemicals, polymers and other fine chemicals.

One of the most popular features that makes bis(trichloromethyl) carbonate (CAS 32315-10-9) a popular substance is its solid form and low evaporation tendency, as well as its commercial availability. However, with a molar mass of 296.75 g/mol, its high toxicity levels also make it relevant in the excipient scenario. Its inhalation alone can lead to biphasic mortality, which is typical of irritant gases – it is a substitute for phosgene in gaseous form – causing injury to both the respiratory tract and the lower respiratory tract. After a few days after the toxic effect, even death can occur.

It is worth mentioning that some of its properties have not yet been analysed, so many of the effects it may cause are probably still unknown. However, it is estimated that the risks would be the same or very similar to those harboured by phosgene.

Over time, triphosgene has been used in organic synthesis as organohalides. Its use means that a wider range of substrates are known that could be truly useful for halogenation. It also has the ability to convert more than one functional group, so it is interesting to consider bis(trichloromethyl) carbonate in the formation of reaction intermediates. It is also used in the preparation of carbonyl chlorides and the activation of carboxylic acids.

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Product information

Catalogue Number: 121020
CAS number: 32315-10-9
EC No: 250-986-3
Formula Hill: C₃Cl₆O₃
Molar Mass: 296,75
HS code: 29209010
Clasification: Superior